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The TRIUMPH-4 Phase 3 trial in obesity with knee osteoarthritis later reported 28.7% mean weight loss at 68 weeks with retatrutide 12 mg/week, and identified a dose-related dysesthesia (nerve-tingling) signal in 8.8% of 9 mg and 20.9% of 12 mg patients (Bays et al., 2025)

Riccio A, Alvania RS, Lonze BE, Ramanan N, Kim T, Huang Y et al

Weeks 4-6: visible transformation The 4-6 week mark is when visual changes become undeniable

The main downside is that injections require more care

Most patients receive lipo shots once per week

This inherent stability allows it to remain biologically active for extended periods, a characteristic that makes it suitable for oral administration in research settings, particularly for studies focused on gastrointestinal health