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Some people may be allergic to certain compounds in cyanocobalamin, making them unsuited for the injections.

The most recent Global Burden of Diseases, Injuries, and Risk Factors (GBD) study reported an age-standardized prevalence rate of 448.6 per 100,000 people in 2021 compared to the 2019 editions cited rate of 599 cases per 100,000 people [2,3,4]

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B12 also aids in DNA synthesis and red blood cell production