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95% CI 7/7 6/6 + 6/7 Odds RatioInnocenti 3/6 (50%) 3/53 (6%) 16.7 2.3 - 120.6Rouits 4/7 (57%) 10/66 (15%) 7.5 1.4 - 38.5Marcuelloa 4/10 (40%) 18/85 (21%) 2.5 0.6 - 9.7Andob 4/7 (57%) 22/111 (20%) 5.4 1.1 - 25.9aGr 3+ neutropenia.bGr 4 leukopenia and/or Gr 3+ diarrhea
Indeed, GLS inhibitors have shown promising tumor-suppressive activities in preclinical models for 968 and bis-2-(5-phenylacetamido-1,3,4-thiadiazol-2-yl)ethyl sulfide (BPTES), or even in clinical models for CB-839 [100,101]
Products are screened for heavy metals, microbials, and common contaminants
However, studies with larger sample groups are needed to observe a statistically significant difference
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