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It is found on the plasma membrane, facing extracellularly, playing an essential role in the maintenance of intracellular cysteine (Moriarty-Craige and Jones, 2004)

"Efficacy and Safety of Cagrilintide in Combination with Semaglutide in Adults with Obesity: The REDEFINE 1 Randomized Clinical Trial." Journal of the American Medical Association, 2024, 331(5): 385-397

Type 2 diabetes: sensitization, not just weight Diabetes trials measure a different baseline and endpoint than obesity trials

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How does weight loss differ with and without diabetes