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Interestingly, only iron, and not other metals, such as zinc, that also cause ROS generation via the Fenton reaction [51], can induce ferroptosis

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However, inhibition of endonuclease activity of APE1, rather than REDOX function, could interact with NPM1 to trigger p53-mediated effects on colon cancer cell metabolism and improve its sensitivity to targeted drugs [22]

The SOD assay is designed to measure the activity of superoxide dismutase enzyme (SOD) from whole blood

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