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Furthermore, evidence indicates that NRF2 can transcriptionally upregulate CHAC1, as observed in ferroptosis-resistant melanoma cells where CHAC1 induction occurs independently of ER stress (Gagliardi et al., 2019) and modestly at the promoter level ( de novo GSH synthesis (Kre et al., 2023)

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Clin Microbiol Rev (2020) 33(4):119

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Glutathione is generally well tolerated by most adults, although some studies have linked long-term consumption with lower zinc levels