Reconstituted retatrutide should never be frozen
But it does show that in a particularly high-BMI subgroup that stayed on treatment and tolerated therapy, weight loss continued to deepen over time
Sugino N, Karube-Harada A, Taketani T, Sakata A, Nakamura Y (2004) Withdrawal of ovarian steroids stimulates prostaglandin F2alpha production through nuclear factor-kappaB activation via oxygen radicals in human endometrial stromal cells: potential relevance to menstruation
Sources & references New England Journal of Medicine Triple-Hormone-Receptor Agonist Retatrutide for Obesity - A Phase 2 Trial Jastreboff AM, Kaplan LM, Fras JP, et al
Often the first benefit patients notice typically within one to two weeks
Cancer prevention methods should be considered, and a new category of pharmaceutical weight loss provides a potentially promising potential chemo-prevention strategy