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DOI Ionescu M, Frohman LA

What SURMOUNT-1 Showed: Tirzepatide's Lean Mass Profile Tirzepatide drives greater overall weight loss than semaglutide, and that comes with a corresponding lean mass cost

It is important to note that there is no official clinical evidence suggesting that morning or night dosing provides superior glycaemic control or weight loss outcomes for most injectable GLP-1 preparations

The effect is minor if stored consistently at 28C

Oral small molecules, therefore, fall into one of four BCS categories depending on their solubility and permeability characteristics ( Table 3 )