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Under normal physiologic conditions, intracellular GSH concentrations of neurons are 250- to 500-fold higher than in the CSF, 17 thus limiting the utility of CSF to serve as a biomarker of cellular GSH status

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10.1016/j.chemphyslip.2008.02.009 57

This review emphasizes the advantages of in vitro methods in meeting the challenges of TCM multicomponent analysis, including the ability to study component interactions and screen potential drug candidates

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