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The plurality of mechanisms of HDACi-induced cell death reflects both the multiple substrates of HDACs and the heterogeneous patterns of molecular alterations present in different cancer cells
Adding dual-PI3K/ inhibitor Duvelisib during CAR T cell manufacture yields cells with an enhanced number of memory subsets, normalized CD4/CD8 ratios, increased mitochondrial mass, and epigenetic modifications correlating with enhanced anti-tumor efficacy (239)
Computational studies suggest that certain tripeptides may function as vehicles for drug delivery systems
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