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Description

The GLP-1 receptor is the shared backbone of both molecules and of the wider drug class, including semaglutide

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( A ) Representative image showing specific expression of TeNT-2A-EGFP in LS GLP-1R neurons

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In diet-induced obese mice, chronic Retatrutide dosing produced greater reductions in adipose mass and food intake than matched-exposure Semaglutide or Tirzepatide comparators, with indirect calorimetry showing increased energy expenditure attributable to the GCGR component and reduced hepatic triglyceride content on histology

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J Drug Deliv Ther 11(2):188193 Shahid RK, Ahmed S, Le D, Yadav S (2021) Diabetes and cancer: risk, challenges, management and outcomes

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