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The ADA and Kidney Disease Improving Global Outcomes (KDIGO) guidelines recommend using SGLT2is with demonstrated benefit in reducing CKD progression and CV events in individuals who have type 2 diabetes with an eGFR of 20 mL/min/1.73 m 2 (KDIGO, 2022
Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocytespecific deletion of JAK2
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The usage of GLP-1 drugs like Ozempic and Wegovy doubled between 2024 and 2025, according to one Gallup study
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however, it seems unlikely that hepatocytes express the canonical GLP-1 receptor (168)
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