In the STEP 1 extension study for semaglutide, participants who stopped the drug after 68 weeks regained about two-thirds of their lost weight within a year
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Key Takeaways 24.2% weight loss at 48 weeks with 12mg dose, the highest efficacy seen in any GLP-1 class medication trial 93% of participants on 12mg achieved 15% weight loss
additional controlled studies are warranted to define safety, dosing, and efficacy parameters in new contexts.
The authors noted that, within the context of their focus on the chloroplast, NADPH could be produced from the photosynthetic electron transport chain (thus providing an additional sink for electrons) or, in the dark, by the dehydrogenases of the oxidative pentose phosphate pathway (Foyer and Halliwell 1976)
Another option, of course, is to bring along a cooler or insulated bag with gel ice packs to keep your medication cold while traveling