Vegetarians and vegans are advised to consume fortified foods or take B12 supplements to maintain adequate levels
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The most important unresolved safety-related research gaps include long-duration exposure, broader dose-response toxicology, sex-specific effects, reproductive and developmental endpoints, hematology, immune monitoring, genotoxicity assessment, and comprehensive off-target profiling across methyltransferase and non-methyltransferase targets
Nursing care: Use proper IM technique, rotate sites, educate patient on side effects and schedule
According to the National Heart, Lung, and Blood Institute, this absorption failure makes B12 injections the primary and most effective treatment, as they deliver the nutrient directly where your body can use it, bypassing the digestive system entirely
The study involved 130 ALS patients (74 men and 56 women) whose symptoms began within one year of enrollment and who progressed at a moderate rate, defined as a 12 point decrease in their ALSFRS-R scores over the three months preceding the trial