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From a strategic perspective, METRNL illustrates the limitations of purely receptor-centric approaches to peptide drug discovery

There are five known melanocortin receptors, and MT-2 primarily binds with MC-4R and MC-1R, which are involved in feeding, sexual behavior, and skin pigmentation

Choosing easily digestible foods, particularly during the initial weeks of treatment, supports better tolerance

DAmico M, Di Filippo C, Marfella R, Abbatecola AM, Ferraraccio F, Rossi F et al (2010) Long-term inhibition of dipeptidyl peptidase-4 in Alzheimers prone mice

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There is also little data on these drugs impact on muscle loss