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Ma B, Wang X, Ren H, Li Y, Zhang H, Yang M, et al
Elevated TMAO levels were connected to severe illness states and a poor prognosis, with higher levels indicating worse outcomes even when controlling for confounders
In the 16th century, Toyotomi Hideyoshi chose Osaka as the location for his castle, and the city may have become Japan's political capital if Tokugawa Ieyasu had not terminated the Toyotomi lineage after Hideyoshi's death and established his government in distant Edo (Tokyo)
Negative energy balance and weight loss can activate the hypothalamic-pituitary-adrenal axis, elevating cortisol levels
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