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Recent trials show that overweight or obese patients saw a 14.9% reduction in body weight after taking once-weekly semaglutide 2.4 mg for 68 weeks, compared to a 2.4% reduction in body weight for the control [24]

One 2025 review in Osteoporosis International found that GLP-1s enhanced bone remodeling and also decreased bone mineral density over time, leaving the authors to raise questions over the possibility of future bone fractures

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doi: 10.1016/bs.acc.2018.07.004 33 TeskeyG.CaoR.IslamogluH.MedinaA.PrasadC.PrasadR.et al