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Currently, there is an ongoing randomised double-masked placebo-controlled trial, the SUMMIT trial, studying the efficacy and safety of tirzepatide, a dual agonist of glucose-dependent insulinotropic polypeptide and GLP-1 receptors, versus placebo in HFpEF patients with obesity (NCT04847557)

This allows for higher total doses and hydration support

The abdomen typically has consistent subcutaneous fat depth and good absorption

Tikellis C, Wookey PJ, Candido R, Andrikopoulos S, Thomas MC, Cooper ME

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It defends cellular macromolecules against exogenous and endogenous reactive oxygen and nitrogen species