There has been increased interest in time-restricted eating and intermittent fasting to improve metabolic variables, although with mixed, and modest, results
(2) Nanoparticles have more complex formulations compared with small-molecule drugs, and their physicochemical properties, such as size, structure, composition, and surface characteristics, all affect the form of nanomedicine preparations in the body, moreover, the physicochemical characteristics of nanoparticles change significantly after administration due to interactions with biomolecules (such as protein coronas), making the evaluation of their in vivo performance difficult (247)
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