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The vast majority of IGF-1 is secreted by the liver (Laron, 2001) with tissues like skeletal muscle also contributing to IGF-1 release during resistance exercise (Perrone et al., 1995)
Complementary approaches may include: Behavioral therapy or weight management counseling Sleep optimization (79 hours nightly) Stress management techniques Evaluation and treatment of coexisting conditions (insulin resistance, sleep apnea, depression) FDA-approved oral weight loss medications (orlistat, phentermine/topiramate ER, naltrexone/bupropion) as alternatives to injectables (note: phentermine monotherapy is approved for short-term use only) Patients should maintain realistic expectationsweight loss may be slower with hypothyroidism, even when well-controlled
How digital health companies are capitalizing on the GLP-1 boom, CNBC, May 25, 2024
It is considered one of the cleaner growth hormone secretagogues due to its ability to selectively bind to ghrelin receptors without overstimulating other hormones like cortisol or prolactin
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