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The uptake of retinol, from the blood, occurs in response to the binding of RBP4-retinol complexes to the plasma membrane receptor identified as STRA6 (stimulated by retinoic acid 6)

The increased oxidative stress seems to be the second hit in the progression from NAFL to NASH: the increase in ROS and consequently in lipid peroxidation has been associated to hepatocellular damage, inflammation, and eventual fibrosis due to the activation of hepatic stellate cells

However, Halbirk et al

It has shown positive preliminary results in several studies of glutathiones ability to affect levels of reactive oxygen species, which may have implications in the reduction of cancer rates

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