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The study confirmed that FOXO4-DRI disrupts FOXO4-p53 binding in endothelial cells, facilitating phosphorylated p53 nuclear exclusion and triggering the BAX/caspase-3 apoptotic cascade specifically in senescent endothelial cells
Sorafenib and erastin can activate the NFE2L2 pathway, resulting in the expression of antioxidant genes such as quinone oxidoreductase 1 (NQO1) and metallothionein 1G (MT1G) in HCC cells (87, 89)
The microbiome plays a crucial role in maintaining the hosts physiological balance and is closely linked to the onset and progression of various diseases [280,281,282]
Pediatr Res 47 : 221224 Laborie S, Lavoie JC, Pineault M, Chessex P 2000 Contribution of multivitamins, air, and light in the generation of peroxides in adult and neonatal parenteral nutrition solutions
Alcohol Res Health
doi: 10.1074/jbc.M805287200 89 ChenKKirberMTXiaoHYangYKeaneyJFJr.Regulation of ROS signal transduction by NADPH oxidase 4 localization
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