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The latter effects are mediated through receptors in the central nervous system such as the caudal hindbrain area postrema and the hypothalamic arcuate [2]

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1,2 Serum vitamin B 12 levels may be artificially elevated in patients with alcoholism, liver disease, or cancer because of decreased hepatic clearance of transport proteins and resultant higher circulating levels of vitamin B 12

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Many individuals can resume modified activity during mid-phase, with progressive loading helping direct tissue remodeling along functional lines