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The data announced on 2 February came from the high-dose, 2.4mg cohorts

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The identity of metabolites was confirmed based on the retention time and accurate m / z of authentic synthesized chemical standards from Sigma-Aldrich, as well as MS2 fragmentation patterns available in HMDB ( and mzCloud database ( Natural isotope correction was performed with AccuCor2 R code ( Labelled ion counts refer to the sum of all labelled forms, in which each form is weighted by the fraction of carbon atoms labelled

Socaa K, Szopa A, Serefko A, Poleszak E, Wla P