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With semaglutide, over 85% of participants achieved 5% weight loss, and about a third lost 20% or more

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The honest answer is that the human safety data is limited compared to decades-old pharmaceuticals, but the preclinical safety record across multiple species is unusually clean for a peptide with this level of biological activity

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These studies consistently report favourable renal outcomes (e.g., eGFR, macroalbuminuria, or serum creatinine levels) with GLP-1 receptor agonists