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The 2.4 mg weekly maintenance dose is where the phase 3 monotherapy trials showed the strongest results, with an average body weight reduction of 11.8% over 68 weeks

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In an ischemic stroke rat model, pretreatment with melatonin for mitochondrial transfer has been found to reduce the area of brain infarction [93]

And it produces the steady-state pharmacokinetics that allow once-weekly dosing

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