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During this exam, the doctor gently inserts a lubricated, gloved finger into the rectum to assess for any abnormalities, such as lumps or tenderness, which can indicate the presence of internal hemorrhoids

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Additionally, in vitro experiments revealed that ICA inhibits the increase in CTGF and p-Drp1 Ser616 in a dose-dependent manner, while increasing p-Drp1 Ser637, MFN1, MFN2, TFAM, and ATP6