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In the PNS, thiamine deficiency can result in polyneuritis and paralysis, as seen in dry beriberi, which affects the sensory system, causing pain, altered temperature sensitivity, numbness, reduced tendon reflexes, and leg atrophy (6, 11, 36)

Therefore, targeted enhancement of the GSH system along with prevention of ferroptosis in the myocardium is a promising therapeutic strategy

Current Medicinal Chemistry

When used topically, Vitamin C can be up to 20 times more potent than when taken orally, making it a go-to ingredient for many skincare enthusiasts

A healthcare provider decides on the suitable method based on what fits the patients goals and what they can tolerate best

doi: 10.18553/jmcp.2025.31.5.441 69 LongoS.RizzaS.FedericiM