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SGLT2is exert beneficial hemodynamic effects, resulting in reduced preload, afterload, and intraglomerular pressure [6, 21]

Based on the results, we selected the optimal dose of Ex which reduced food intake without observable side effects and went on to investigate the hypothesised meal schedule dependent effects of Ex (see Fig

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However, it has also demonstrated significant nootropic effects

Rectal body temperature Conscious mice were restrained and a high-precision thermometer (BIO-TK8851, Bioseblab) was carefully inserted half-way into the rectum

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