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Native IGF-1 added to cell culture media at the start of a 72-hour experiment will be substantially degraded and sequestered by the end of that window, even in serum-free conditions

For instance, chimeric antigen receptor macrophages (CAR-Ms) targeting fibroblast activation protein (FAP) can effectively phagocytose activated cardiac fibroblasts, markedly attenuating cardiac fibrosis and improving function following myocardial ischemia-reperfusion injury (188, 189)

"The lowest doses of these medications are usually given at first and then gradually increased so people have less chance of developing side effects," he says

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doi:10.1530/JOE-10-0419 47