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10.1172/jci194745 J
TLR signalling augments macrophage bactericidal activity through mitochondrial ROS
Consistent trends were observed for each component of the composite endpoint and for all-cause death
A total of 92.6% ( n = 14,507) of patients had a second prescription fill, 84.8% ( n = 13,282) had a third, and 74.1% ( n = 11,615) had a fourth prescription fill
Common adverse effects are predominantly gastrointestinal and typically emerge during dose escalation: Nausea (affecting 2050% of users initially) Vomiting and diarrhoea Constipation Abdominal pain and bloating Reduced appetite (therapeutic effect but may be excessive) Fatigue and headache Injection site reactions (redness, swelling or itching) These effects usually diminish over several weeks as the body adjusts
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