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The HCO 3 is derived from the TCA cycle-mediated oxidation of the 2-oxoglutarate that results from the glutaminase and glutamate dehydrogenase reactions
This evidence supports the safety of taking both medications, provided you monitor for worsening side effects and communicate with your healthcare provider
Research from the SURMOUNT-4 trial specifically demonstrated that patients who discontinued tirzepatide regained significant weight compared to those who continued treatment
Some insurance plans cover one medication but not the other
Jumping straight to a high dose would increase the likelihood of side effects such as nausea and digestive discomfort
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