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Mounjaro was approved by the FDA in 2022 as a GIP and GLP-1 receptor agonist for improving blood sugar control in adults with type 2 diabetes, and subsequent trials went on to evaluate its effects specifically on body weight in people with obesity or overweight

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This was achieved by inhibiting bone resorption through an increase in the OPG/RANKL ratio and promoting bone formation by enhancing the expression of osteoblast-specific transcription factors

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more Lemme Bestsellers The maintenance phase has different metabolic needs, different gut dynamics, and far less support available, noted Valenton

Three distinct mechanisms