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What Semaglutide Provides Clinical trials demonstrate significant cardiovascular benefits: Event reduction: The SELECT trial showed 20% reduction in major cardiovascular events (heart attack, stroke, cardiovascular death) with semaglutide in patients with obesity and established heart disease
Personal Opinion: Having reviewed hundreds of case reports and clinical studies, I believe testosterone optimization represents the single most underutilized tool in mens metabolic health
The following are key considerations to inform that decision
This review lays that out with fair-balance framing rather than a recommendation, current as of April 2026
What followed may prove to be a structural turning point not just for Novo, but for the entire compounded GLP-1 market and, by extension, for my other key holding, WW International
A 2021 meta-analysis of 18 randomized controlled studies showed significant drops in fat-free mass with GLP-1 drugs, including oral and subcutaneous semaglutide and older GLP-1 drugs such as lixisenatide, exenatide, and liraglutide
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