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New England Journal of Medicine , 368: 1575-1584 Zhu W, et al
In fact, NADH is an inhibitor of the TCA enzyme isocitrate dehydrogenase 93 , a protective mechanism to prevent overloading of the ETC and excessive ROS generation
The antidiabetic drug metformin activates the AMP-activated protein kinase cascade via an adenine nucleotide-independent mechanism
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