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Dulaglutides safety profile is consistent with other GLP-1 receptor agonists, with transient nausea being the most frequently reported adverse event (14.6% incidence). Dose escalation from 0.75 to 1.5 mg is recommended after at least four weeks, based on individual glycemic control needs [57]
However, for patients with chronic kidney disease (CKD) , these medications require careful dosing to avoid risks like dehydration, electrolyte imbalances, and acute kidney injury
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MTHFR polymorphism and psychiatric diseases Extensive clinical studies demonstrated a significant linkage between MTHFR polymorphism and various diseases, such as cardiovascular diseases, neuronal developmental diseases, cancers as well as psychiatric disorders
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