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requiring multiple injections in a short time

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If you experience sweating while taking tirzepatide, several strategies can help manage this symptom and improve overall treatment tolerance: For hypoglycemia-related sweating: Monitor blood glucose regularly, especially if taking insulin or sulfonylureas Carry fast-acting carbohydrates (glucose tablets, juice) at all times Follow the "15-15 rule" per American Diabetes Association guidance: consume 15 grams of carbohydrate, wait 15 minutes, and recheck glucose Discuss with your doctor whether adjustment of other diabetes medications is needed If you're at risk for severe hypoglycemia, ask your doctor about glucagon rescue medication For general sweating management: Maintain adequate hydration by drinking water throughout the day, particularly if experiencing gastrointestinal side effects Wear breathable, moisture-wicking fabrics that allow heat dissipation Keep the sleeping environment cool and use lightweight bedding if experiencing night sweats Avoid known triggers such as spicy foods, caffeine, or alcohol, which can exacerbate sweating Practice stress-reduction techniques including deep breathing, meditation, or gentle exercise For gastrointestinal side effects that may contribute to sweating: Eat smaller, more frequent meals rather than large portions Choose bland, easily digestible foods during the initial treatment period Avoid high-fat, greasy, or heavily spiced foods that may worsen nausea Take tirzepatide consistently on the same day each week, with or without food as preferred General treatment optimization: Work closely with your healthcare provider to ensure appropriate dose escalation according to the FDA-approved schedule for your specific medication (Mounjaro or Zepbound)

But the patient is still actively engaged in their treatment, not passively receiving a medication and hoping it fixes everything

Day 0 (the day prednisone is prescribed): Continue Zepbound on the regular weekly schedule Get a baseline finger-stick glucose if you have a meter, or note your continuous glucose monitor (CGM) reading Plan to monitor glucose 2 to 4 times daily during the steroid course Have a Tums or Pepcid plan in case reflux flares Days 1-5 (the steroid course): Take prednisone in the morning with food, as prescribed Continue Zepbound on schedule Check fasting glucose first thing in the morning Check post-meal glucose 2 hours after lunch and dinner Hydrate well (steroids increase thirst

MAESTRO-NASH Investigators