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A 2007 clinical trial conducted in Russia found that epithalon can normalize the hormone circadian rhythm in elderly test subjects and increase nighttime levels of melatonin in subjects with pineal gland functional insufficiency [13]

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Limitations of the current study included the single ethnicity design, lack of histopathological and molecular assessment tools of GLP-1RAs-mediated cellular changes and lack of sequential invasive tools in assessment of altered gallbladder motility