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UKPDS 34: Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes
Originally developed to reduce excess visceral fat in people living with HIV-associated lipodystrophy, it has since attracted broader interest for its potential effects on metabolism, body composition, and healthy aging
In a large phase 3 obesity trial (ACHIEVE-1), orforglipron at daily doses of 3, 12 and 36 mg caused approximately: Diarrhoea: 1926% of participants (vs 9% on placebo) Nausea: 1318% (vs 2% on placebo) Constipation: 817% (vs 4% on placebo) Vomiting: 514% (vs 1% on placebo) Across multiple studies, 617% of people stopped treatment because of side effects, mostly gut-related symptoms
The traditional Chinese medicines are widely used to treat liver diseases in China and other East Asian countries
Citation: Hughes, Tyler B., Grover Paul Miller, and S
Patients must mix the powder with at least 6-8 ounces of water or a preferred beverage, and ensure they are consuming ample hydrating fluids throughout the day
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