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AMPK activation suppresses key fibrotic signalling pathways, including TGF-/Smad and NFB, resulting in inhibition of fibroblast proliferation and reduced ECM protein production [19]

Mechanisms of Glycemic Control (The Pancreas) The primary mechanism for glycemic control involves the activation of GLP-1 receptors (GLP-1R) on pancreatic islet cells, initiating intracellular signaling cascades such as the cAMP/PKA and PI3K/Akt pathways (Figure 1)(Zheng et al., 2024)

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