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Lacticaseibacillus rhamnosus HA-114 and Bacillus subtilis R0179 prolong lifespan and mitigate amyloid- toxicity in C
Riboflavin deficiency-implications for general human health and inborn errors of metabolism
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The reported outcome of this campaign was a candidate that retained agonist activity at amylin/calcitonin-family receptors while displaying a markedly extended pharmacokinetic profile in the authors' preclinical models, and reduced food intake in rodent models following administration
A limited effect on the pK a value of the glutathione thiol by the same mutation suggested that the evolutionarily conserved Arg15 makes a major contribution to ionization of the thiol group
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