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Therefore, for subsequent analyses to provide actionable clinical probabilities, it is essential to select endpoints with consistent definitions and stable network connectivity (e.g., weight) and discuss their effect sizes and uncertainties within a standardized time window
The chart below shows timing considerations for common combinations
Furthermore, the data showed that both the ROS scavenger N -acetylcysteine (NAC) and GSH compensator GSH-MEE could abrogate APR-017 and LCS3 induced increase in ROS, decrease in GSH and inhibition of cell growth in VRK2-KO cells (Fig
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