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The Sitagliptin CVOT In the Trial Evaluating Cardiovascular Outcomes with Sitagliptin (TECOS) study, 14,671 patients with type 2 diabetes and established cardiovascular disease were randomized to addition of sitagliptin or placebo to existing therapy for a median follow-up period of 3.0 years

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The accumulated data indicate that mitochondria, mTOR, and autophagy may represent an integral regulatory axis during ASD [16, 251, 253, 308]