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LOMA LINDA, Calif., Jan

However, the design of SURPASS-4 was based on the change in HbA 1c at 52 weeks, and not on MACE, as the primary outcome [21]

in the early 2020s

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While the study concluded that short-term DSIP treatment was unlikely to be of major therapeutic benefit noting that statistically significant effects were weak and partly attributable to incidental placebo group change it provided the most methodologically rigorous human sleep architecture dataset for DSIP and confirmed the compounds specific effect on objective, not merely subjective, sleep quality parameters

Support for clinical significance came from a responder analysis based on an anchored assessment, which evaluated participants perception of benefit