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Step 1: Dietary and lifestyle changes Increase soluble fiber gradually to 25-30 grams per day (psyllium husk, oats, chia seeds, ground flaxseed) Drink 64-80 oz of water daily, spread throughout the day Add prunes or prune juice (4-6 prunes or 4-8 oz juice daily) Increase physical activity, especially walking (stimulates colonic motility) Establish a consistent bathroom routine (same time each day, usually 20-30 minutes after breakfast) About 40% of patients with mild GLP-1 constipation see improvement within 7-10 days of consistent dietary changes alone

doi: 10.1016/S0076-6879(94)33026-3 20 MartnezMCAndriantsitohainaR

OKane M, Parretti HM, Pinkney J, et al

This albumin-binding mechanism extends the compound half-life in biological research models to approximately seven days

Nature , 562(7728), 578-582