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View Study [3]"IGF-I and IGFBP-3 transport in the rat heart" Boes M, Dake BL, et al., 2003 Finding: This study showed that LR3 IGF-I can bypass IGF binding proteins that normally sequester IGF-1, demonstrating why LR3 has greater bioactivityit reaches target tissues more effectively than native IGF-1

The changes in HDL-C, triglycerides, and total cholesterol were similar in STEP-1 and SELECT, and there remained a significant decrease in LDL-C even though patients started at a lower LDL-C level [33, 48]

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