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A common research framing is a defined block (often 812 weeks) followed by an off period, rather than indefinite continuous use a conservative default given the absence of long-term human data

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10.1016/j.brs.2014.07.031 35 ConsidineR

Those who opted out of injections in the past may now reconsider using GLP-1 knowing pills are an option, she said

Increased concentrations of blood TMAO have a strong link with increased major adverse cardiovascular events and all-cause mortality 13,14

doi:10.1080/10606820213687