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Finally, the small sample size of patient-derived PBMCs limits the ability to perform multivariable analysis, underscoring the importance of integrating these data with animal models

In addition, Knapen (221) also found that the use of incretin drugs could increase the risk of pancreatic cancer by 1.7 times

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Using his RIA he was able to show that in the fasting state glucagon gets released in addition to insulin to raise plasma glucose