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The gap is in large-scale human randomised controlled trials, which have not yet been conducted
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Avermectin Derivatives, Pharmacokinetics, Therapeutic and Toxic Dosages, Mechanism of Action, and Their Biological Effects
Prolonged UVB exposure activates melanocytes, increasing melanin content, which accelerates pigmentation and potentially contributes to various skin disease such as freckles ( 2.2.2 Genetic inheritance or inflammation Pigmentation disorders can result from various factors, including inflammation and genetic inheritance (Tearle et al., 2025)
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