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The size of the benefit varies by drug and by how sick the patients were, but the pattern held

In contrast, isoleucine and valine largely serve as metabolic substrates and display weaker activation of translational signaling

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This results in activation of two major canonical signaling pathways: the IRS-1/PI3K/Akt pathway, which is linked to most metabolic actions, such as stimulation of glucose uptake, lipogenesis, glycogen synthesis, and inhibition of gluconeogenesis, and the Shc/Grb2/Sos/Ras/Raf/MAPK pathway, which regulates cell growth and differentiation (5, 7)